
Proceedings Paper
Monitoring closed head injury induced changes in brain physiology with orthogonal diffuse near-infrared reflectance spectroscopyFormat | Member Price | Non-Member Price |
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Paper Abstract
We applied an orthogonal diffuse reflectance spectroscopy (o-DRS) to assess brain physiology following closed head
injury (CHI). CHI was induced in anesthetized male mice by weight-drop device using ~50gram cylindrical metal
falling from a height of 90 cm onto the intact scalp. A total of twenty-six mice were used in the experiments divided
randomly into three groups as follows: Group 1 (n=11) consisted of injured mice monitored for 1 hour every 10
minutes. Group 2 (n=10) were the control mice not experience CHI. Group 3 (n=5) consisted of injured mice
monitored every minute up to 20 minutes. Measurement of optical quantities of brain tissue (absorption and reduced
scattering coefficients) in the near-infrared window from 650 to 1000 nm were carried out by employing different
source-detector distances and locations to provide depth sensitivity. With respect to baseline, we found difference in
brain hemodynamic properties following injury. In addition, o-DRS successfully evaluate the structural variations
likely from evolving cerebral edema throughout exploring the scattering spectral shape.
Paper Details
Date Published: 5 March 2014
PDF: 9 pages
Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 89280J (5 March 2014); doi: 10.1117/12.2035438
Published in SPIE Proceedings Vol. 8928:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
Henry Hirschberg M.D.; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)
PDF: 9 pages
Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 89280J (5 March 2014); doi: 10.1117/12.2035438
Show Author Affiliations
Marlon S. Mathews, Univ. of California Irvine Medical Ctr. (United States)
Published in SPIE Proceedings Vol. 8928:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
Henry Hirschberg M.D.; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)
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