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Proceedings Paper

Significance of threshold doses for photodynamic therapy of melanotic and amelanotic tumors
Author(s): Joerg G. Moser; R. Suchomski; Till Danielowski; Birgit Wagner; H. Scheer; G. Hartwich
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Paper Abstract

The decay of the surviving cell fraction, F, during photodynamic treatment of a cell population, F0, vs. energy dose obeys an exponential law. The integrated logarithmic form yields a straight line with intercept 0 and slope -k. The reciprocal slope yields LD90, i.e., the energy fluence (J/cm2) necessary to kill 90% of the cell population F0. In reality there are deviations from this simple set of equations. At low power densities most photosensitizers are unable to kill cells. This leads to an `optical threshold' without cell destruction but frequently with cell stimulating effects, so called `overshots.' This general phenomenon occurs in a very pronounced form with melanotic melanoma cells.

Paper Details

Date Published: 1 March 1995
PDF: 9 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203446
Show Author Affiliations
Joerg G. Moser, Heinrich-Heine-Univ. (Germany)
R. Suchomski, Heinrich-Heine-Univ. (Germany)
Till Danielowski, Heinrich-Heine-Univ. (Germany)
Birgit Wagner, Heinrich-Heine-Univ. (Germany)
H. Scheer, Univ. of Munich (Germany)
G. Hartwich, Univ. Muenchen (Germany)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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