In order to develop tumor-localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT-DO1 and has a molecular formula of m-phthalyl-{[13,17-bispropanoic acid-3-ethenyl-8-formylethylidene-7- hydroxy-2,7,12,18-tetramethyl-porphyrinate]-manganese (III)]}-(3'-ethenyl-8'- formylethylidene-7'-hydroxy-2',7',12',18'-tetramethyl-porphine-13',17'- bispropanoyl aspartic acid)-bishydrazone.

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203442

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)