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Proceedings Paper

Enhanced photodynamic therapy and dosimetry by light-induced fluorescence
Author(s): Daniel Braichotte; Jean-Francois Savary; Philippe Monnier; Hubert van den Bergh
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Paper Abstract

For a given light and photosensitizer dose the degree of reaction of a tissue after photodynamic therapy (PDT) with tetra(meta-hydroxyphenyl)chlorin (mTHPC) shows large differences from one patient to another. This can be explained by variation of the photosensitizer (PS) concentration in the tissue of interest and can lead to undertreatment of the lesion and overtreatment of the surrounding normal tissue. A better prediction of the degree of reaction can be obtained by taking into account the drug concentration measured by light induced fluorescence (LIF) and by adjusting the light dose consequently.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203436
Show Author Affiliations
Daniel Braichotte, Swiss Federal Institute of Technology (Switzerland)
Jean-Francois Savary, CHUV Hospital (Switzerland)
Philippe Monnier, CHUV Hospital (Switzerland)
Hubert van den Bergh, Swiss Federal Institute of Technology (Switzerland)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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