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Proceedings Paper

New approach for treatment of advanced malignant tumors: combination of chemotherapy and photodynamic therapy
Author(s): Lian-xing Wang; Hua-lamg Ju; Zhem-ming Chem
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Paper Abstract

Eighty-three patients suffering from moderate or advanced malignant tumors were treated by combined chemotherapy and photodynamic therapy (PDT) in our hospital. The short term result of such management is very promising, the effectiveness seems to be nearly 100% and the general responsive rate is 79.5% (CR + PR). If compared with another group of 84 similar patients whom were treated with PDT alone, the short term efficacy is 85.7% while the general response rate is 54.7% (P < 0.01), there is a significant statistic. The better result of the combined approach is probably due to the action of the chemotherapeutic agent, potentially blocking the mitosis of the cellular cycle at certain phases of the cancer cells, making the cell membrane become more permeable to the photochemical agent, HPD, and eliciting a better cancerocidal effect.

Paper Details

Date Published: 1 March 1995
PDF: 6 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203422
Show Author Affiliations
Lian-xing Wang, Xiaoshan Laser Hospital (China)
Hua-lamg Ju, Xiaoshan Laser Hospital (China)
Zhem-ming Chem, Xiaoshan Laser Hospital (China)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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