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Proceedings Paper

Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice
Author(s): Cathrin Dressler; M. Samy Ismail; Simone Stroebele; Christian Nowak; Ralf Herter; Rainier G. Senz; Roland Hagemann; Peter Koeppe; Beate Roeder; Hans-Peter Berlien
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Paper Abstract

The phthalocyanines form a continuously growing family of potential photosensitizers. Their chemical and photophysical properties, and therefore their photodynamic activities, are influenced by the type of the central metal ion as well as the type and localization of substituents. Plasma and tissue distribution kinetics are also dependent on the chemical features of a dye molecule. We therefore investigated the pharmacokinetics of newly synthesized octa-(alpha) -butyloxy-zincphthalocyanine (8-(alpha) -bo-ZnPc) on the Lewis lung carcinoma in order to evaluate the application possibilities of this compound in experimental PDT treatments. The zinc complex was chosen on the basis of the known effect of this metal on the photochemical and photophysical properties of phthalocyanines. The pharmacokinetics of octa-(alpha) -butyloxy-zincphthalocyanine were studied on the Lewis lung carcinoma by absorption spectroscopy in mice. Afterwards a regression analysis was performed using the absorption spectroscopic data.

Paper Details

Date Published: 1 March 1995
PDF: 10 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203413
Show Author Affiliations
Cathrin Dressler, Freie Univ. Berlin and Laser-Medizin-Zentrum Berlin GmbH (Germany)
M. Samy Ismail, Freie Univ. Berlin (Germany)
Simone Stroebele, Freie Univ. Berlin (Germany)
Christian Nowak, Max-Delbrueck-Centrum (Germany)
Ralf Herter, Technische Fachhochschule Berlin and Humboldt Univ. Berlin (Germany)
Rainier G. Senz, Laser-Medizin-Zentrum Berlin GmbH and Technische Fachhochschule Berlin (Germany)
Roland Hagemann, Laser-Medizin-Zentrum Berlin GmbH (Germany)
Peter Koeppe, Freie Univ. Berlin (Germany)
Beate Roeder, Humboldt Univ. Berlin (Germany)
Hans-Peter Berlien, Freie Univ. Berlin and Laser-Medizin-Zentrum Berlin GmbH (Germany)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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