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Proceedings Paper

Measurements of sensitizer fluorescence in patients by means of an ordinary fluorescence spectrometer
Author(s): Johan Moan; Elfrid Hoydalsvik; Qian Peng; Li Wei Ma; Trond Warloe; Helen Heyerdahl
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Paper Abstract

An ordinary fluorescence spectrometer equipped with a dichroic mirror and fiber optics can be used to measure sensitizer fluorescence in tumors and normal tissues. Our findings with such an instrument showed that after oral administration of 60 mg/kg 5-aminolevulinic acid (ALA) mucosas and rectal adenomas fluoresced stronger than normal skin. Also basal cell carcinomas (BCCs) showed a stronger porphyrin fluorescence than skin after topical application of ALA. The porphyrin fluorescence of BCCs decayed rapidly during standard laser irradiation at 630 nm. The degradation rate of porphyrins in the tumor was approximately constant down to at least 0.3 mm below the tumor surface, in agreement with an optical penetration depth of more than 1 mm.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995);
Show Author Affiliations
Johan Moan, The Norwegian Radium Hospital (Norway)
Elfrid Hoydalsvik, The Norwegian Radium Hospital (Norway)
Qian Peng, The Norwegian Radium Hospital (Norway)
Li Wei Ma, The Norwegian Radium Hospital (Norway)
Trond Warloe, The Norwegian Radium Hospital (Norway)
Helen Heyerdahl, The Norwegian Radium Hospital (Norway)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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