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Proceedings Paper

Photodynamic therapy of normal canine prostate
Author(s): Qun Chen; Sugandh D. Shetty M.D.; Brian C. Wilson; Michael S. Patterson; Larry Heads; Daniel Schultz; Joseph C. Cerny M.D.; H. Chen; Fred W. Hetzel
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Paper Abstract

To provide basic scientific information for utilizing photodynamic therapy to treat prostatic carcinoma, PDT dosimetry and effective treatment volume were investigated using canine prostate as an in vivo animal model. The prostate glands were surgically exposed. Isotropic tip fibers were inserted into the gland for either light irradiation or detection. PDT doses of 400 J and 1, 3 or 5 mg/kg Photofrin were used for single fiber irradiation treatments. All animals were terminated at 1 week and the prostates evaluated histopathologically. The results show that the lesion size was dependent on the treatment dose. The maximum lesion dimension was approximately 1.6 cm. The data acquired from the single fiber irradiation study were then used to plan for multi-fiber interstitial PDT treatments with a goal of achieving a larger treatment volume for practical purpose. The data indicate that the lesion size from the multiple fiber treatment could be predicted based on the single fiber treatment with the light pattern summed from all sources.

Paper Details

Date Published: 1 March 1995
PDF: 6 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203386
Show Author Affiliations
Qun Chen, Presbyterian/St. Luke's Medical Ctr. (United States)
Sugandh D. Shetty M.D., Henry Ford Hospital (United States)
Brian C. Wilson, Princess Margaret Hospital (Canada)
Michael S. Patterson, Hamilton Regional Cancer Ctr. (Canada)
Larry Heads, Henry Ford Hospital (United States)
Daniel Schultz, Henry Ford Hospital (United States)
Joseph C. Cerny M.D., Henry Ford Hospital (United States)
H. Chen, Presbyterian/St. Luke's Medical Ctr. (United States)
Fred W. Hetzel, Presbyterian/St. Luke's Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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