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Proceedings Paper

Sensitization and photodynamic therapy of esophageal, duodenal, and colonic tumors with 5-aminolaevulinic acid (ALA) induced protoporphyrinIX (PPIX)
Author(s): Peter Mlkvy; Helmut Messmann; Jaroslaw Regula; M. Conio; M. Pauer; Charles E. Millson; Alexander J. MacRobert; Stephen G. Bown
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Paper Abstract

Five aminolaevulinic acid (ALA) is a promising agent for PDT sensitization as it can be given orally and only causes skin photosensitivity for 1 - 2 days. In fluorescence and photodynamic studies 26 patients with benign and malignant gastrointestinal tumors (M 17, F 9; mean age 79) were given 30 - 60 mg ALA orally (single or divided doses) and biopsies taken of tumor and normal tissue at 1 - 24 hours for fluorescence microscopy. With 30 mg/kg, highest protoporphyrin IX (PPIX) levels were seen in oesophagus, duodenum and less in colon, but without tumor selectivity. Better tumor selectivity was seen in the colon after 60 mg/kg (5:1). Six patients had transient rises in transaminases and five mild nausea. Sixteen patients were later treated (after further ALA) with red light (628 nm, bare fiber or diffuser, 50 - 100 J at 50 mW at each site). All but two showed subsequent necrosis, but only 0.5 - 1.5 mm depth. PDT with ALA is simple, safe, and promising for tumors in the GI tract. Modification of treatment parameters may make it suitable for larger lesions.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203379
Show Author Affiliations
Peter Mlkvy, National Cancer Ctr. (Slovak Republic)
Helmut Messmann, Univ. of Regensburg (Germany)
Jaroslaw Regula, Univ. College London Medical School (United Kingdom)
M. Conio, Univ. College London Medical School (United Kingdom)
M. Pauer, National Cancer Ctr. (Slovak Republic)
Charles E. Millson, Univ. College London Medical School (United Kingdom)
Alexander J. MacRobert, Univ. College London Medical School (United Kingdom)
Stephen G. Bown, Univ. College London Medical School (United Kingdom)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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