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Proceedings Paper

Potentiation of photodynamic therapy by granulocyte-macrophage colony stimulating factor immunotherapy
Author(s): Gorazd Krosl; Mladen Korbelik; Jana Krosl; Graeme J. Dougherty
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Paper Abstract

The murine squamous carcinoma cell line (SCCVII) was genetically engineered to produce high levels of granulocyte-macrophage colony stimulating factor (GM-CSF). Lethally irradiated GM-CSF producing cells were injected under the subcutaneously growing parental SCCVII tumor at various times before and/or after PDT. Even a single treatment with GM- CSF producing cells injected two days before PDT markedly enhanced the tumor cure rate when compared to the PDT treatment alone. Effective potentiation was observed with PDT mediated either by Photofrin or by benzoporphyrin derivative.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203373
Show Author Affiliations
Gorazd Krosl, British Columbia Cancer Agency (Canada)
Mladen Korbelik, British Columbia Cancer Agency (Canada)
Jana Krosl, British Columbia Cancer Agency (Canada)
Graeme J. Dougherty, British Columbia Cancer Agency (Canada)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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