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Proceedings Paper

Nanosensors for next generation drug screening
Author(s): Sridhar K. Kannam; Matthew T. Downton; Natalie Gunn; Sung Cheol Kim; Priscilla R. Rogers; Christine Schieber; Julia S. Baldauf; John M. Wagner; Daniel Scott; Ross Bathgate; Stan Skafidas; Stefan Harrer
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Paper Abstract

One promising path for future drug screening technologies is to examine the binding of ligands to target proteins at the single molecule level by passing them through nanometer sized pores and measuring the change in pore current during translocation. With the aim of evaluating such technologies we perform virtual experiments on the translocation of proteins through silicon nitride nanopores. These simulations consist of large scale, fully atomistic models of the translocation process that involve steering a test protein through the nanopore on a timescale of tens of nanoseconds. We make a comparison between theoretically expected and simulated values of the current drop that is seen when the protein occupies the pore. Details of the stability of the protein and the preservation of its function as measured by its secondary and tertiary structure will be presented to validate both the simulation results and the fundamental design of the proposed device. Finally, the results will be placed in the context of experimental work that combines nanofabrication and microuidics to create a high throughput, low cost, drug screening device.

Paper Details

Date Published: 7 December 2013
PDF: 7 pages
Proc. SPIE 8923, Micro/Nano Materials, Devices, and Systems, 89230I (7 December 2013); doi: 10.1117/12.2033737
Show Author Affiliations
Sridhar K. Kannam, IBM Research Australia (Australia)
Matthew T. Downton, IBM Research Collaboratory for Life Sciences-Melbourne (Australia)
Natalie Gunn, IBM Research Australia (Australia)
Sung Cheol Kim, IBM Research Australia (Australia)
Priscilla R. Rogers, IBM Research Australia (Australia)
Christine Schieber, IBM Research Australia (Australia)
Julia S. Baldauf, IBM Research Australia (Australia)
John M. Wagner, IBM Research Collaboratory for Life Sciences-Melbourne (Australia)
Daniel Scott, The Univ. of Melbourne (Australia)
Ross Bathgate, The Univ. of Melbourne (Australia)
Stan Skafidas, The Univ. of Melbourne (Australia)
Stefan Harrer, IBM Research Australia (Australia)

Published in SPIE Proceedings Vol. 8923:
Micro/Nano Materials, Devices, and Systems
James Friend; H. Hoe Tan, Editor(s)

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