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Proceedings Paper

Serum levels of hematoporphyrin derivatives in the photodynamic therapy of malignant tumors
Author(s): H. K. Chan; K. S. Low; A. S. Haji Baba; S. Arimbalam; C. H. Yip; K. W. Chang; G. Baskaran; Y. L. Lo; P. Jayalakshmi; L. M. Looi; N. H. Tan
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Paper Abstract

In photodynamic therapy (PDT), red light is administered 24 - 72 hours post intravenous (i.v.) injection of hematoporphyrin derivatives (HpD). In an earlier animal model study, more effective therapeutic response was obtained when red light irradiation was carried out 15 mins after the injection of HpD. The effectiveness of this immediate PDT protocol has been correlated to the high serum level of HpD immediately after administration and the destruction of the microcirculation system as the dominant tumor destruction mechanism. This study examines the pharmacokinetics and the serum levels of HpD in rats and also in human patients. Such data can assist in defining the optimum time delay for light irradiation in the PDT of cancer.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995);
Show Author Affiliations
H. K. Chan, Univ. of Malaya (Malaysia)
K. S. Low, Univ. of Malaya (Malaysia)
A. S. Haji Baba, Univ. of Malaya (Malaysia)
S. Arimbalam, Univ. of Malaya (Malaysia)
C. H. Yip, Univ. of Malaya (Malaysia)
K. W. Chang, Univ. of Malaya (Malaysia)
G. Baskaran, Univ. of Malaya (Malaysia)
Y. L. Lo, Univ. of Malaya (Malaysia)
P. Jayalakshmi, Univ. of Malaya (Malaysia)
L. M. Looi, Univ. of Malaya (Malaysia)
N. H. Tan, Univ. of Malaya (Malaysia)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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