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Proceedings Paper

Model of the haem biosynthetic pathway
Author(s): Jeanette Greaves-Brown; Tim J. Williams; J. H. Parish
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Paper Abstract

(delta) -Aminolaevulinic acid (ALA) is a photodynamic therapy (PDT) agent that utilizes the haem biosynthetic pathway to create therapeutic levels of photoactive agents within tissues. Photosensitizer dosimetry and drug concentrations in target tissues are areas of uncertainty within PDT research. A program is described that uses numerical methods to model mathematically the haem biosynthetic pathway from ALA to haem as a set of partial differential rate equations. The data generated allow analysis and correlation with functions describing the kinetic behavior governing the reactions. This analysis provides insight into the production of protoporphyrin IX and other photoactive agents from exogenous ALA and provides a method for optimizing parameters, and for highlighting metabolic steps to which the product formation is most sensitive.

Paper Details

Date Published: 1 March 1995
PDF: 3 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995);
Show Author Affiliations
Jeanette Greaves-Brown, Univ. of Leeds (United Kingdom)
Tim J. Williams, Univ. of Leeds (United Kingdom)
J. H. Parish, Univ. of Leeds (United Kingdom)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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