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Proceedings Paper

Therapeutic effectiveness of selected protoporphyrin derivatives in treatment of lung sarcoma (sarcoma L1)
Author(s): E. Pirozynska; M. Kalczak; Edward Stanowski M.D.; M. Kupsc; Alfreda Graczyk; Jerzy Konarski
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Paper Abstract

The effectiveness of two preparations used as photosensitizers in the photodynamic method for neoplasm treatment was examined. The material consisted of Balb/c strain mice with transplanted lung sarcoma, Sarcoma L1. Arginine derivative HpDArg2 (hematoporphyrin derivatives -- arginine) and PP(Phen2Arg2, i.e., 1-arginine di(N- phenylalanyl) protoporphyrinate, were used as photosensitizers. Animals were administered the photosensitizer in a dose of 10 mg/kg body weight. After 24 hrs they were irradiated with He-Ne laser; total energy of 150 J/cm2 was applied in three portions of 50 J/cm2 each, at 24-h intervals. The results showed that PP(Phen)2Arg2 destroyed Sarcoma L1 much more effectively than the conventionally used mixture of hematoporphyrin derivatives, customarily named HpD.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2203, Laser Technology IV: Applications in Medicine, (1 March 1995); doi: 10.1117/12.203331
Show Author Affiliations
E. Pirozynska, Central Hospital of Medical Military Academy (Poland)
M. Kalczak, Central Hospital of Medical Military Academy (Poland)
Edward Stanowski M.D., Central Hospital of Medical Military Academy (Poland)
M. Kupsc, Central Hospital of Medical Military Academy (Poland)
Alfreda Graczyk, Military Univ. of Technology (Poland)
Jerzy Konarski, Military Univ. of Technology (Poland)

Published in SPIE Proceedings Vol. 2203:
Laser Technology IV: Applications in Medicine
Wieslaw L. Wolinski; Tadeusz Kecik, Editor(s)

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