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Proceedings Paper

Assessing fluctuating evolutionary pressure in yeast and mammal evolutionary rate covariation using bioinformatics of meiotic protein genetic sequences
Author(s): Sunil Dehipawala; A. Nguyen; G. Tremberger Jr.; E. Cheung; T. Holden; D. Lieberman; T. Cheung
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Paper Abstract

The evolutionary rate co-variation in meiotic proteins has been reported for yeast and mammal using phylogenic branch lengths which assess retention, duplication and mutation. The bioinformatics of the corresponding DNA sequences could be classified as a diagram of fractal dimension and Shannon entropy. Results from biomedical gene research provide examples on the diagram methodology. The identification of adaptive selection using entropy marker and functional-structural diversity using fractal dimension would support a regression analysis where the coefficient of determination would serve as evolutionary pathway marker for DNA sequences and be an important component in the astrobiology community. Comparisons between biomedical genes such as EEF2 (elongation factor 2 human, mouse, etc), WDR85 in epigenetics, HAR1 in human specificity, clinical trial targeted cancer gene CD47, SIRT6 in spermatogenesis, and HLA-C in mosquito bite immunology demonstrate the diagram classification methodology. Comparisons to the SEPT4-XIAP pair in stem cell apoptosis, testesexpressed taste genes TAS1R3-GNAT3 pair, and amyloid beta APLP1-APLP2 pair with the yeast-mammal DNA sequences for meiotic proteins RAD50-MRE11 pair and NCAPD2-ICK pair have accounted for the observed fluctuating evolutionary pressure systematically. Regression with high R-sq values or a triangular-like cluster pattern for concordant pairs in co-variation among the studied species could serve as evidences for the possible location of common ancestors in the entropy-fractal dimension diagram, consistent with an example of the human-chimp common ancestor study using the FOXP2 regulated genes reported in human fetal brain study. The Deinococcus radiodurans R1 Rad-A could be viewed as an outlier in the RAD50 diagram and also in the free energy versus fractal dimension regression Cook’s distance, consistent with a non-Earth source for this radiation resistant bacterium. Convergent and divergent fluctuating evolutionary pressure could be studied with extension to genetic sequences in organisms in possible astrobiology conditions, with the assumption that the continuation of a book of life would require meiotic proteins everywhere in the universe.

Paper Details

Date Published: 26 September 2013
PDF: 18 pages
Proc. SPIE 8865, Instruments, Methods, and Missions for Astrobiology XVI, 88650H (26 September 2013); doi: 10.1117/12.2024633
Show Author Affiliations
Sunil Dehipawala, Queensborough Community College (United States)
A. Nguyen, Queensborough Community College (United States)
G. Tremberger Jr., Queensborough Community College (United States)
E. Cheung, Queensborough Community College (United States)
T. Holden, Queensborough Community College (United States)
D. Lieberman, Queensborough Community College (United States)
T. Cheung, Queensborough Community College (United States)

Published in SPIE Proceedings Vol. 8865:
Instruments, Methods, and Missions for Astrobiology XVI
Richard B. Hoover; Gilbert V. Levin; Alexei Yu. Rozanov; Nalin C. Wickramasinghe, Editor(s)

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