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Proceedings Paper

New iron-oxide particles for magnetic nanoparticle hyperthermia: an in-vitro and in-vivo pilot study
Author(s): Mohammad Hedayati; Anilchandra Attaluri; David Bordelon; R. Goh; Michael Armour; Haoming Zhou; Christine Cornejo; Michele Wabler; Yonggang Zhang; Theodore DeWeese; Robert Ivkov
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Paper Abstract

Magnetic nanoparticle hyperthermia (mNHP) is regarded as a promising minimally invasive procedure. These nanoparticles generate heat when exposed to alternating magnetic fields (AMFs) and thus have shown a potential for selective delivery of heat to a target such as a cancer cell. Despite the great promise however, successful clinical translation has been limited in part by technical challenges of selectively delivering heat only to the target tissue. Interaction of AMF with tissues also deposits heat through Joule heating via eddy currents. Considerations of patient safety thus constrain the choice of AMF power and frequency to values that are insufficient to produce desirable heating from available nanoparticle formulations. Therefore, considerable effort must be directed to the design of particles and the AMF device to maximize the specific delivery of heat to the intended target while minimizing the unintended and non-specific heating. We have recently developed new iron-oxide nanoparticles (IONPs) having much higher heating capability at the clinically relevant amplitudes and frequencies than other formulations. Here, we utilize a new rectangular coil designed for treating multi well tissue culture plate and show that these particles are superior to two commercially available IONPs for hyperthermia of DU145 prostate cancer cells in culture. We report results of pilot in-vivo experiments using the DU145 human prostate xenograft model in nude male mouse. AMF treatment yielded an intratumor temperature rise > 10 °C in <10 min heating (AMF amplitude 29 kA/m @160 kHz) with ~4 mg nanoparticle /g tumor while maintaining rectal (core) temperature well within physiological range.

Paper Details

Date Published: 22 February 2013
PDF: 10 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 858404 (22 February 2013); doi: 10.1117/12.2019834
Show Author Affiliations
Mohammad Hedayati, Johns Hopkins Univ. School of Medicine (United States)
Anilchandra Attaluri, Johns Hopkins Univ. School of Medicine (United States)
David Bordelon, Johns Hopkins Univ. School of Medicine (United States)
R. Goh, Nanomaterials Technology, Plc, Ltd. (Singapore)
Michael Armour, Johns Hopkins Univ. School of Medicine (United States)
Haoming Zhou, Johns Hopkins Univ. School of Medicine (United States)
Christine Cornejo, Johns Hopkins Univ. School of Medicine (United States)
Michele Wabler, Johns Hopkins Univ. School of Medicine (United States)
Yonggang Zhang, Johns Hopkins Univ. School of Medicine (United States)
Theodore DeWeese, Johns Hopkins Univ. School of Medicine (United States)
Robert Ivkov, Johns Hopkins Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)

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