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Proceedings Paper

Lab-on-a disc platform for particle focusing induced by inertial forces
Author(s): Maria Kitsara; Gerson R. Aguirre; Vitaly Efremov; Jens Ducree
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Paper Abstract

Dean forces have been consistently used in microfluidic mixing units and recently also have been utilized to separate particles in inertial force driven systems by secondary flows. Microfluidic separation systems using inertial forces created by curved asymmetric channels have already been established in the literature. In the present work, we propose a centrifugal lab-on-a-disc platform, which can provide focusing of particles of 21μm diameter size and high separation of two different density types of particles (polystyrene and silica) using of both the inertial focusing forces and sedimentation forces. This comprises the primary advantage of the proposed platform compared to a pump-driven system. This platform can be utilized for the separation of different types of cells bound to specifically-functionalized particles of different densities.

Paper Details

Date Published: 28 May 2013
PDF: 7 pages
Proc. SPIE 8765, Bio-MEMS and Medical Microdevices, 87650R (28 May 2013); doi: 10.1117/12.2017438
Show Author Affiliations
Maria Kitsara, Dublin City Univ. (Ireland)
Gerson R. Aguirre, Dublin City Univ. (Ireland)
Vitaly Efremov, Dublin City Univ. (Ireland)
Jens Ducree, Dublin City Univ. (Ireland)

Published in SPIE Proceedings Vol. 8765:
Bio-MEMS and Medical Microdevices
Angeliki Tserepi; Manuel Delgado-Restituto; Eleni Makarona, Editor(s)

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