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Proceedings Paper

Radiant energy during infrared neural stimulation at the target structure
Author(s): Claus-Peter Richter; Suhrud Rajguru; Ryan Stafford; Stuart R. Stock
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Paper Abstract

Infrared neural stimulation (INS) describes a method, by which an infrared laser is used to stimulate neurons. The major benefit of INS over stimulating neurons with electrical current is its spatial selectivity. To translate the technique into a clinical application it is important to know the energy required to stimulate the neural structure. With this study we provide measurements of the radiant exposure, at the target structure that is required to stimulate the auditory neurons. Flat polished fibers were inserted into scala tympani so that the spiral ganglion was in front of the optical fiber. Angle polished fibers were inserted along scala tympani, and rotating the beveled surface of the fiber allowed the radiation beam to be directed perpendicular to the spiral ganglion. The radiant exposure for stimulation at the modiolus for flat and angle polished fibers averaged 6.78±2.15 mJ/cm2. With the angle polished fibers, a 90º change in the orientation of the optical beam from an orientation that resulted in an INS-evoked maximum response, resulted in a 50% drop in the response amplitude. When the orientation of the beam was changed by 180º, such that it was directed opposite to the orientation with the maxima, minimum response amplitude was observed.

Paper Details

Date Published: 8 March 2013
PDF: 7 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85655P (8 March 2013); doi: 10.1117/12.2013849
Show Author Affiliations
Claus-Peter Richter, Northwestern Univ. (United States)
Suhrud Rajguru, Univ. of Miami (United States)
Ryan Stafford, Lockheed Martin Aculight (United States)
Stuart R. Stock, Northwestern Univ. Feinburg School of Medicine (United States)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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