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Proceedings Paper

Photodynamic therapy of locally advanced pancreatic cancer (VERTPAC study): final clinical results
Author(s): M. T. Huggett; M. Jermyn; A. Gillams; S. Mosse; E. Kent; S. G. Bown M.D.; T. Hasan; B. W. Pogue; S. P. Pereira
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Paper Abstract

We undertook a phase I dose-escalation study of verteporfin photodynamic therapy (PDT) in 15 patients with locally advanced pancreatic cancer. Needle placement and laser delivery were technically successful in all patients. Thirteen patients were treated with a single laser fibre. Three treatments were carried out each at 5, 10 and 20 J/cm2; and 5 treatments (4 patients) at 40 J/cm2. A further 2 patients were treated with 2 or 3 laser fibres at 40 J/cm2. Tumour necrosis was measured on CT (computed tomography) by two radiologists 5 days after treatment. There was a clear dosedependent increase in necrosis with a median area of 20 x 16 mm (range 18 x 16 to 35 x 30 mm) at 40 J/cm2. In the 2 patients treated with multiple fibres, necrosis was 40 x 36 mm and 30 x 28 mm, respectively. There were no early complications in patients treated with a single fibre. Both patients treated with multiple fibres had evidence on CT of inflammatory change occurring anterior to the pancreas but without clinical deterioration. These results suggest that single fibre verteporfin PDT is safe in a clinical setting up to 40J/cm2 and produces a dose-dependent area of pancreatic necrosis.

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680J (13 March 2013); doi: 10.1117/12.2013648
Show Author Affiliations
M. T. Huggett, Univ. College London (United Kingdom)
M. Jermyn, Thayer School of Engineering at Dartmouth (United States)
A. Gillams, Univ. College Hospital (United Kingdom)
S. Mosse, Univ. College London (United Kingdom)
E. Kent, Univ. College Hospital (United Kingdom)
S. G. Bown M.D., Univ. College London (United Kingdom)
T. Hasan, Wellman Ctr. for Photomedicine, Massachusetts General Hospital, Harvard Medical School (United States)
B. W. Pogue, Thayer School of Engineering at Dartmouth (United States)
S. P. Pereira, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 8568:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
David H. Kessel; Tayyaba Hasan, Editor(s)

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