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Proceedings Paper

Effect of low level laser therapy (LLLT) on vestibular system after gentamicin ototoxicity
Author(s): ChungKu Rhee M.D.; Jai-Hwan Hyun; Myung-Whan Suh; Jin Chul Ahn M.D.; Jae Yun Jung M.D.
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Paper Abstract

Aim: To develop a bilateral vestibulopathy animal model induced by gentamicin using RS rat and to see the effect of LLLT on this bilateral vestibulopathy model. Method: RS rats were divided into 3 groups, control group (C), laser group (L), and histology group (H). All animals in the 3 groups received gentamicin (GM) 110 mg/kg, intravenously once daily for 3 days. The animals underwent sinusoidal oscillation about a vertical axis before the GM injection, 1, 3, and 7 days post injections. Transcanal low level laser therapy (LLLT) was irradiated to left ear canal for 7 days, starting 1 day post the GM injection. The H group animals were irradiated into the left ear of L group for 3 days, starting 1 day post GM injections for 3 days. C and L groups were sacrifice on 9th day and H group was sacrificed on 7th day. Results: The gain of the C group was significantly decreased in 3 and 7 days. The gain of the right ear of L group was decreased significantly in 3 and 7 days. The gain of left ear of L group was decreased in 3 days post LLLT but the decreased gain was improved significantly comparing to the level of 7 days gain of right ear and it was much closer to the pre-GM level. The average number of cells in cupula of H group after laser treatment for 3 days was significantly lower in non laser treated right ear comparing to the laser treated left ear and ears of the normal rats. Conclusion: The present study demonstrated that LLLT restores vestibular function and vestibular hair cells in rats post gentamicin induced ototoxic damage. LLLT may have clinical implications in the treatment of various vestibular dysfunction. Further studies are essential to verify the exact mechanisms and the most effective application of LLLT to rescue vestibular dysfunction.

Paper Details

Date Published: 8 March 2013
PDF: 8 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651S (8 March 2013); doi: 10.1117/12.2012581
Show Author Affiliations
ChungKu Rhee M.D., Dankook Univ. College of Medicine (Korea, Republic of)
Jai-Hwan Hyun, Dankook Univ. College of Medicine (Korea, Republic of)
Myung-Whan Suh, Dankook Univ. College of Medicine (Korea, Republic of)
Jin Chul Ahn M.D., Dankook Univ. College of Medicine (Korea, Republic of)
Jae Yun Jung M.D., Dankook Univ. College of Medicine (Korea, Republic of)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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