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Proceedings Paper

Sensing a heart infarction marker with surface plasmon resonance spectroscopy
Author(s): Ulrich Kunz; Andreas Katerkamp; Reinhard Renneberg; Friedrich Spener; Karl Cammann
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Paper Abstract

In this study a direct immunosensor for heart-type fatty acid binding protein (FABP) based on surface plasmon resonance spectroscopy (SPRS) is presented. FABP can be used as a heart infarction marker in clinical diagnostics. The development of a simple and cheap direct optical sensor device is reported in this paper as well as immobilization procedures and optimization of the measuring conditions. The correct working of the SPRS device is controlled by comparing the signals with theoretical calculated values. Two different immunoassay techniques were optimized for a sensitive FABP-analysis. The competitive immunoassay was superior to the sandwich configuration as it had a lower detection limit (100 ng/ml), needed less antibodies and could be carried out in one step.

Paper Details

Date Published: 10 February 1995
PDF: 10 pages
Proc. SPIE 2331, Medical Sensors II and Fiber Optic Sensors, (10 February 1995); doi: 10.1117/12.201250
Show Author Affiliations
Ulrich Kunz, Westfaelische Wilhelms-Univ. (Germany)
Andreas Katerkamp, Westfaelische Wilhelms-Univ. (Germany)
Reinhard Renneberg, Westfaelische Wilhelms-Univ. (Germany)
Friedrich Spener, Westfaelische Wilhelms-Univ. (Germany)
Karl Cammann, Westfaelische Wilhelms-Univ. (Germany)

Published in SPIE Proceedings Vol. 2331:
Medical Sensors II and Fiber Optic Sensors
Anna Maria Verga Scheggi; Francesco Baldini; Pierre R. Coulet; Otto S. Wolfbeis, Editor(s)

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