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Proceedings Paper

Biomolecular hydrogel-based lipid bilayer array system
Author(s): Joseph Najem; Alex Edgerton; Donald J. Leo
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Paper Abstract

This work investigates the fabrication of hydrogel based lipid bilayers arrays using micro fabrication technologies that enable high precision in controlling the cell-scale droplets. Arrays of hydrogels that support curved aqueous lenses are deposited on two parallel substrates using lithography techniques on top of a network of Ag/AgCl electrodes. The first step in the fabrication process is to deposit silver electrodes using silver paint through a mask, a layer of silver chloride is then formed around the silver channels using another mask with the desired geometry. The hydrogel arrays are then achieved by exposing a thin film of photocrosslinkable hydrogel to UV light through a mask. Hydrogel arrays are fabricated using this technique, which is represents a relatively accurate and inexpensive method. The hydrogel structures can host a thin aqueous curved lenses containing phospholipids . Bilayer arrays can be formed by using a technique similar to the regulated attachment method, where mechanical force is used to bring adjacent aqueous lenses in contact.

Paper Details

Date Published: 8 April 2013
PDF: 6 pages
Proc. SPIE 8686, Bioinspiration, Biomimetics, and Bioreplication 2013, 86860C (8 April 2013); doi: 10.1117/12.2010695
Show Author Affiliations
Joseph Najem, Virginia Polytechnic Institute and State Univ. (United States)
Alex Edgerton, Virginia Polytechnic Institute and State Univ. (United States)
Donald J. Leo, Virginia Polytechnic Institute and State Univ. (United States)

Published in SPIE Proceedings Vol. 8686:
Bioinspiration, Biomimetics, and Bioreplication 2013
Raúl J. Martín-Palma, Editor(s)

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