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Proceedings Paper

Bionanocomposites based on layered double hydroxides as drug delivery systems
Author(s): Pilar Aranda; Ana C. S. Alcântara; Ligia N. M. Ribeiro; Margarita Darder; Eduardo Ruiz-Hitzky
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Paper Abstract

The present work introduces new biohybrid materials involving layered double hydroxides (LDH) and biopolymers to produce bionanocomposites, able to act as effective drug delivery systems (DDS). Ibuprofen (IBU) and 5-aminosalicylic acid (5-ASA) have been chosen as model drugs, being intercalated in a Mg–Al LDH matrix. On the one side, the LDHIBU intercalation compound prepared by ion-exchange reaction was blended with the biopolymers zein, a highly hydrophobic protein, and alginate, a polysaccharide widely applied for encapsulating drugs. On the other side, the LDH- 5-ASA intercalation compound prepared by co-precipitation was assembled to the polysaccharides chitosan and pectin, which show mucoadhesive properties and resistance to acid pH values, respectively. Characterization of the intercalation compounds and the resulting bionanocomposites was carried out by means of different experimental techniques: X-ray diffraction, infrared spectroscopy, chemical and thermal analysis, as well as optical and scanning electron microscopies. Data on the swelling behavior and drug release under different pH conditions are also reported.

Paper Details

Date Published: 24 October 2012
PDF: 8 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85486D (24 October 2012); doi: 10.1117/12.2008317
Show Author Affiliations
Pilar Aranda, Instituto de Ciencia de Materiales de Madrid, CSIC (Spain)
Ana C. S. Alcântara, Instituto de Ciencia de Materiales de Madrid, CSIC (Spain)
Ligia N. M. Ribeiro, Instituto de Ciencia de Materiales de Madrid, CSIC (Spain)
Univ. de São Carlos (Brazil)
Margarita Darder, Instituto de Ciencia de Materiales de Madrid, CSIC (Spain)
Eduardo Ruiz-Hitzky, Instituto de Ciencia de Materiales de Madrid, CSIC (Spain)

Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee M.D.; Vijay K. Varadan, Editor(s)

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