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Proceedings Paper

Determination of the optical coefficients of in vivo biological tissues by analysis of the coherent backscattering line shape
Author(s): Miles H. Eddowes; Timothy N. Mills; David T. Delpy
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Paper Abstract

Precise knowledge of the optical coefficients of a turbid biological medium is fundamental to the analysis of many optical therapeutic and diagnostic techniques that can now be found in medicine. It is unfortunate that the few successful techniques that have been developed for the measurement of absorption and reduced scattering coefficients have been limited to in vitro samples where the optical properties are almost certain to be significantly different to the corresponding in vivo state. The analysis of coherent backscattering peak lineshapes using an analytical solution derived from a scalar diffusion approximation has been recently reported but the results were inconsistent with the coefficients measured with an established method. The progress of this present study has resulted in the development of a Monte Carlo simulation of coherent backscatter from biological media which can cope with many of the practical limitations and theoretical simplifications that have been encountered (e.g., refractive index mismatches and a finite illumination spot size). Our initial results have highlighted the inaccuracies in the earlier study and suggest a novel strategy that may be used to determine the absorption and effective scattering coefficients of in vivo tissues with minimal invasion under clinical conditions.

Paper Details

Date Published: 31 January 1995
PDF: 10 pages
Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995); doi: 10.1117/12.200812
Show Author Affiliations
Miles H. Eddowes, Univ. College London (United Kingdom)
Timothy N. Mills, Univ. College London (United Kingdom)
David T. Delpy, Univ. College London (United Kingdom)

Published in SPIE Proceedings Vol. 2326:
Photon Transport in Highly Scattering Tissue
Sigrid Avrillier; Britton Chance; Gerhard J. Mueller; Alexander V. Priezzhev; Valery V. Tuchin, Editor(s)

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