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Proceedings Paper

Energy dispersive X-ray diffraction computed tomography of breast-simulating phantoms and a tissue sample
Author(s): Shyma M. Alkhateeb; Mohamed H. Abdelkader; David A. Bradley; Paul Seller; Matthew C. Veale; Matt D. Wilson; Silvia Pani
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Paper Abstract

Breast lesions and normal tissue have different characteristics of density and molecular arrangement that affect their diffraction patterns. X-ray diffraction can be used to determine the spatial structure of such tissues at the atomic and molecular level and Energy Dispersive X-Ray Diffraction Computed Tomography (EDXRDCT) can be used to produce 2-dimensional images of cross sections of the samples. The purpose of this work is to use an EDXRDCT system to find the limiting visibility for details that simulate breast lesions. Results are presented for EDXRDCT images of samples of different materials simulating breast tissue contrast and shapes. For simple circular details, the contrast between details and background in the images was measured with the goal of simulating the contrast between real breast tissue components. The limiting visible diameter was measured as a function of detail diameter for different combinations of scanning and geometrical parameters. Images of more complex test objects were assessed in terms of both contrast and accuracy of shape reproduction, evaluating the feasibility of using shape analysis as an additional parameter for lesion identification. The optimum combination of parameters are intended to be applied to the scanning of waxed breast tissue blocks.

Paper Details

Date Published: 19 March 2013
PDF: 11 pages
Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86684G (19 March 2013); doi: 10.1117/12.2007710
Show Author Affiliations
Shyma M. Alkhateeb, Univ. of Surrey (United Kingdom)
King Abdulaziz Univ. (Saudi Arabia)
Mohamed H. Abdelkader, Univ. of Surrey (United Kingdom)
Ain Shams Univ. (Egypt)
David A. Bradley, Univ. of Surrey (United Kingdom)
Paul Seller, Rutherford Appleton Lab. (United Kingdom)
Matthew C. Veale, Rutherford Appleton Lab. (United Kingdom)
Matt D. Wilson, Rutherford Appleton Lab. (United Kingdom)
Silvia Pani, Univ. of Surrey (United Kingdom)

Published in SPIE Proceedings Vol. 8668:
Medical Imaging 2013: Physics of Medical Imaging
Robert M. Nishikawa; Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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