
Proceedings Paper
Iron oxide nanoparticle enhancement of radiation cytotoxicityFormat | Member Price | Non-Member Price |
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Paper Abstract
Iron oxide nanoparticles (IONPs) have been investigated as a promising means for inducing tumor cell-specific
hyperthermia. Although the ability to generate and use nanoparticles that are biocompatible, tumor specific, and have the
ability to produce adequate cytotoxic heat is very promising, significant preclinical and clinical development will be
required for clinical efficacy. At this time it appears using IONP-induced hyperthermia as an adjunct to conventional
cancer therapeutics, rather than as an independent treatment, will provide the initial IONP clinical treatment. Due to their
high-Z characteristics, another option is to use intracellular IONPs to enhance radiation therapy without excitation with
AMF (production of heat). To test this concept IONPs were added to cell culture media at a concentration of 0.2 mg
Fe/mL and incubated with murine breast adenocarcinoma (MTG-B) cells for either 48 or 72 hours. Extracellular iron was
then removed and all cells were irradiated at 4 Gy. Although samples incubated with IONPs for 48 hrs did not
demonstrate enhanced post-irradiation cytotoxicity as compared to the non-IONP-containing cells, cells incubated with
IONPs for 72 hours, which contained 40% more Fe than 48 hr incubated cells, showed a 25% decrease in clonogenic
survival compared to their non-IONP-containing counterparts. These results suggest that a critical concentration
of intracellular IONPs is necessary for enhancing radiation cytotoxicity.
Paper Details
Date Published: 26 February 2013
PDF: 6 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840J (26 February 2013); doi: 10.1117/12.2007701
Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)
PDF: 6 pages
Proc. SPIE 8584, Energy-based Treatment of Tissue and Assessment VII, 85840J (26 February 2013); doi: 10.1117/12.2007701
Show Author Affiliations
Courtney M. Mazur, Brown Univ. (United States)
Thayer School of Engineering at Dartmouth (United States)
Jennifer A. Tate, Thayer School of Engineering at Dartmouth (United States)
Rendall R. Strawbridge, Thayer School of Engineering at Dartmouth (United States)
Thayer School of Engineering at Dartmouth (United States)
Jennifer A. Tate, Thayer School of Engineering at Dartmouth (United States)
Rendall R. Strawbridge, Thayer School of Engineering at Dartmouth (United States)
David J. Gladstone, Thayer School of Engineering at Dartmouth (United States)
P. Jack Hoopes, Thayer School of Engineering at Dartmouth (United States)
P. Jack Hoopes, Thayer School of Engineering at Dartmouth (United States)
Published in SPIE Proceedings Vol. 8584:
Energy-based Treatment of Tissue and Assessment VII
Thomas P. Ryan, Editor(s)
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