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Proceedings Paper

Cardiovascular CTA applications: patient-specific contrast formulae
Author(s): C. Saade; R. Bourne; M. Wilkinson; P. Brennan
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Paper Abstract

Clear visualisation of the vertebral arteries is of substantial clinical importance, yet optimisation of contrast administration has not been developed in tandem with recent technological developments in computed tomography (CT). The current work involving 202 patients’ compares the value of a tailored contrast regiment based on patient dynamics and a craniocaudal scan acquisition, with the routine contrast protocol with a caudocranial scan. Attenuation characteristics within 20 arteries were calculated and diagnostic efficacy measured using DBM receiver operating characteristic (ROC) methods. The results demonstrated that the tailored regimen resulted in significantly higher attenuation values (p<0.01) and ROC Az values (p=0.002), along with better inter-observer agreement compared with the routine protocol and contrast volume was reduced by almost 50%. The data demonstrate that patient-specific strategies can result in significant diagnostic benefit.

Paper Details

Date Published: 28 March 2013
PDF: 15 pages
Proc. SPIE 8673, Medical Imaging 2013: Image Perception, Observer Performance, and Technology Assessment, 86731R (28 March 2013); doi: 10.1117/12.2007697
Show Author Affiliations
C. Saade, Royal Prince Alfred Hospital (Australia)
The Univ. of Sydney (Australia)
American Univ. of Beirut (Lebanon)
R. Bourne, The Univ. of Sydney (Australia)
M. Wilkinson, Royal Prince Alfred Hospital (Australia)
P. Brennan, The Univ. of Sydney (Australia)

Published in SPIE Proceedings Vol. 8673:
Medical Imaging 2013: Image Perception, Observer Performance, and Technology Assessment
Craig K. Abbey; Claudia R. Mello-Thoms, Editor(s)

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