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Proceedings Paper

Surface-based prostate registration with biomechanical regularization
Author(s): Wendy J.M. van de Ven; Yipeng Hu; Jelle O. Barentsz; Nico Karssemeijer; Dean Barratt; Henkjan J. Huisman
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Paper Abstract

Adding MR-derived information to standard transrectal ultrasound (TRUS) images for guiding prostate biopsy is of substantial clinical interest. A tumor visible on MR images can be projected on ultrasound by using MRUS registration. A common approach is to use surface-based registration. We hypothesize that biomechanical modeling will better control deformation inside the prostate than a regular surface-based registration method. We developed a novel method by extending a surface-based registration with finite element (FE) simulation to better predict internal deformation of the prostate. For each of six patients, a tetrahedral mesh was constructed from the manual prostate segmentation. Next, the internal prostate deformation was simulated using the derived radial surface displacement as boundary condition. The deformation field within the gland was calculated using the predicted FE node displacements and thin-plate spline interpolation. We tested our method on MR guided MR biopsy imaging data, as landmarks can easily be identified on MR images. For evaluation of the registration accuracy we used 45 anatomical landmarks located in all regions of the prostate. Our results show that the median target registration error of a surface-based registration with biomechanical regularization is 1.88 mm, which is significantly different from 2.61 mm without biomechanical regularization. We can conclude that biomechanical FE modeling has the potential to improve the accuracy of multimodal prostate registration when comparing it to regular surface-based registration.

Paper Details

Date Published: 15 March 2013
PDF: 6 pages
Proc. SPIE 8671, Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling, 86711R (15 March 2013); doi: 10.1117/12.2007580
Show Author Affiliations
Wendy J.M. van de Ven, Nijmegen Medical Ctr., Radboud Univ. (Netherlands)
Yipeng Hu, Univ. College London (United Kingdom)
Jelle O. Barentsz, Nijmegen Medical Ctr., Radboud Univ. (Netherlands)
Nico Karssemeijer, Nijmegen Medical Ctr., Radboud Univ. (Netherlands)
Dean Barratt, Univ. College London (United Kingdom)
Henkjan J. Huisman, Nijmegen Medical Ctr., Radboud Univ. (Netherlands)

Published in SPIE Proceedings Vol. 8671:
Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling
David R. Holmes III; Ziv R. Yaniv, Editor(s)

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