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Proceedings Paper

The ANTs cortical thickness processing pipeline
Author(s): Nicholas J. Tustison; Brian B. Avants; Philip A. Cook; Gang Song; Sandhitsu Das; Niels van Strien; James R. Stone; James C. Gee
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Paper Abstract

Numerous studies have explored the relationship between cortical structure and brain development, cognitive function, and functional connectivity. The highly convoluted cortical topography makes manual measurements arduous and often impractical given the population sizes necessary for sufficient statistical power. Computational techniques have permitted large-scale studies as they provide robust and reliable localized measurements characterizing the cortex with little or no human intervention. Particularly useful to the neuroscience community are publicly available tools, such as the popular surface-based Freesurfer, which facilitate the testing and refinement of hypotheses. In this paper, we introduce the volume-based Advanced Normalization Tools (ANTs) cortical thickness automated pipeline comprising well-vetted components such as SyGN (multivariate template construction), SyN (image registration), N4 (bias correction), Atropos (n-tissue segmentation), and DiReCT (cortical thickness) all developed as part of the ANTs open science effort. Complementing the open source aspect of ANTs we demonstrate its utility using the publicly available IXI data set.

Paper Details

Date Published: 29 March 2013
PDF: 4 pages
Proc. SPIE 8672, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, 86720K (29 March 2013); doi: 10.1117/12.2007128
Show Author Affiliations
Nicholas J. Tustison, Univ. of Virginia (United States)
Brian B. Avants, Univ. of Pennsylvania (United States)
Philip A. Cook, Univ. of Pennsylvania (United States)
Gang Song, Univ. of Pennsylvania (United States)
Sandhitsu Das, Univ. of Pennsylvania (United States)
Niels van Strien, Norwegian Univ. of Science and Technology (Norway)
James R. Stone, Univ. of Virginia (United States)
James C. Gee, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 8672:
Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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