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Proceedings Paper

Motion correction of rodent thoracic PET image using radioactive bead and MRI image
Author(s): Jung Woo Yu; Sang-Keun Woo; Yong Jin Lee; In Ok Ko; Ran Ji Yoo; Joo Hyun Kang; Byung Il Kim; Yong Hyun Chung; Sang Moo Lim; Kyeong Min Kim
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Paper Abstract

PET image of tumor located in thoracic region was affected by various organ motions such as respiration and heartbeat. Thoracic motion is difficult to estimate and correct accurately using external measurement or anatomical image solely. The aim of this study was to compare the accuracy of motion correction using PET fiducial mark and 3D MRI image. The radioactive bead for PET fiducial mark was realized from molecular sieve contained 0.37 MBq F-18 and placed in thoracic region. PET study was performed using a small animal PET scanner after IV injection of FDG. MRI study was performed using 3-T clinical MRI system with 3D T1-VIBE (TR/TE=5.67/1.42 ms) sequence. Motion corrected PET image was created by mutual information registration with B-Spline interpolation to the mean image after first realignment. FWHM of lung and liver region in static PET image was 4.77±0.87 and 4.81±0.45, respectively. Measured FWHM of lung region in motion corrected PET image using PET fiducial mark and 3D VIBE MRI was measured 4.22±0.09 and 4.59±0.06, respectively. In case of liver region, FWHM was measured 4.47±0.16 and 4.65±0.25 respectively. The improvement of resolution was observed by proper correction method. In this study PET correction was implemented by motion information extracted from various images. These results suggest motion correction would be possible without external device or fiducial mark using MRI motion data. Motion correction using MRI should be considered acquisition method and organ region in accordance with motion characteristics.

Paper Details

Date Published: 6 March 2013
PDF: 6 pages
Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 866847 (6 March 2013); doi: 10.1117/12.2007124
Show Author Affiliations
Jung Woo Yu, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Yonsei Univ. (Korea, Republic of)
Sang-Keun Woo, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Yong Jin Lee, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
In Ok Ko, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Ran Ji Yoo, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Joo Hyun Kang, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Byung Il Kim, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Yong Hyun Chung, Yonsei Univ. (Korea, Republic of)
Sang Moo Lim, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)
Kyeong Min Kim, Korea Institute of Radiological and Medical Sciences (Korea, Republic of)


Published in SPIE Proceedings Vol. 8668:
Medical Imaging 2013: Physics of Medical Imaging
Robert M. Nishikawa; Bruce R. Whiting; Christoph Hoeschen, Editor(s)

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