In this paper we show how to use the approximate bilateral symmetry of the brain with respect to its interhemispheric fissure for intra-subject (rigid-body) mono- and multimodal 3D image registration. We propose to define and compute an approximate symmetry plane in the two images to register and to use these two planes as constraints in the registration problem. This 6-parameter problem is thus turned into three successive 3-parameter problems. Our hope is that the lower dimension of the parameter space makes these three subproblems easier and faster to solve than the initial one. We implement two algorithms to solve these three subproblems in the exact same way, within a common intensity-based framework using mutual information as the similarity measure. We compare this symmetry-based strategy with the standard approach (i.e. direct estimation of a 6-parameter rigid-body transformation), also implemented within the same framework, using synthetic and real datasets. We show our symmetry-based method to achieve subvoxel accuracy with better robustness and larger capture range than the standard approach, while being slightly less accurate and slower. Our method also succeeds in registering clinical MR and PET images with a much better accuracy than the standard approach. Finally, we propose a third strategy to decrease the run time of the symmetry-based approach and we give some ideas, to be tested in future works, on how to improve its accuracy.

Date Published: 13 March 2013
PDF: 8 pages
Proc. SPIE 8669, Medical Imaging 2013: Image Processing, 866911 (13 March 2013); doi: 10.1117/12.2007075

Published in SPIE Proceedings Vol. 8669:
Medical Imaging 2013: Image Processing
Sebastien Ourselin; David R. Haynor, Editor(s)