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Proceedings Paper

Dynamic OCE measurement of the biomechanical properties of gelatin phantom and mouse cornea in vivo
Author(s): Jiasong Li; Shang Wang; Ravi Kiran Manapuram; Floredes M. Menodiado; Manmohan Singh; Salavat Aglyamov; Stanislav Emelianov; Michael Twa; Kirill V. Larin
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Paper Abstract

Here we demonstrate our use of phase stabilized swept-source optical coherence elastography (PhS-SSOCE) to assess elastic wave propagation in gelatin phantoms. From these measurements, Young’s moduli of the samples were determined. Low-amplitude (<10μm) mechanical waves were introduced using a focused air pulse on gelatin of different concentrations. Elastic wave amplitude and velocity were measured at multiple points on the phantom surface using a phase-resolved method. The results demonstrate that this method is capable of resolving very small changes in wave amplitude (~ 10 nm) as well as differences in wave velocity due to material stiffness. We further demonstrate use of this method for measurements with a contact lens, a silicone eye model and with the eye of an 18-month-old mouse in vivo. This non-destructive, non-invasive measurement system produces minimal tissue excitation and has high measurement sensitivity. These traits make this make this method useful for in vivo study of the biomechanical properties of ocular and other tissues.

Paper Details

Date Published: 20 March 2013
PDF: 8 pages
Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 85711T (20 March 2013); doi: 10.1117/12.2007033
Show Author Affiliations
Jiasong Li, Univ. of Houston (United States)
Shang Wang, Univ. of Houston (United States)
Ravi Kiran Manapuram, Univ. of Houston (United States)
Floredes M. Menodiado, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Salavat Aglyamov, The Univ. of Texas at Austin (United States)
Stanislav Emelianov, The Univ. of Texas at Austin (United States)
Michael Twa, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)
Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 8571:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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