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Proceedings Paper

Multi-object statistical analysis of late adolescent depression
Author(s): Mahdi Ramezani; Abtin Rasoulian; Purang Abolmaesumi; Tom Hollenstein; Ingrid Johnsrude; Kate Harkness
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Paper Abstract

Shape deformations and volumetric changes in the hippocampus and amygdala have previously been noted in Major Depressive Disorder (MDD). Unfortunately, these analyses are limited because relative shape and pose (rigid+scale transformation) information of multiple objects in brain are generally disregarded. We hypothesize that this information might complement studies of limbic structural deformation in MDD. We focus on changes in temporal (e.g., superior, middle and inferior temporal gyrus) and limbic (e.g., hippocampus and amygdala) lobes. Here, we use a multi-object statistical pose and shape model to analyze imaging data from young people with and without a depressive disorder. Nineteen individuals with a depressive disorder (mean age: 17.85) and twenty six healthy controls (age: 18) were enrolled in the study. A segmented atlas in MNI space has been used to segment hippocampus, amygdala, parahippocampal gyri, putamen, and the superior, inferior and middle temporal gyri in both hemispheres of the brain. Points on the surface of each structure were extracted and warped to each subjects’ structural MRI. These corresponding surface points were used within the analysis, to extract the pose and shape features. Pose and shape differences were detected between the two groups, such that second principal mode of pose variation (p = 0.022), and first principal mode of shape variation (p = 0.049) were found to differ significantly between the two groups.

Paper Details

Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8669, Medical Imaging 2013: Image Processing, 86690D (13 March 2013); doi: 10.1117/12.2007013
Show Author Affiliations
Mahdi Ramezani, The Univ. of British Columbia (Canada)
Abtin Rasoulian, The Univ. of British Columbia (Canada)
Purang Abolmaesumi, The Univ. of British Columbia (Canada)
Tom Hollenstein, Queen's Univ. (Canada)
Ingrid Johnsrude, Queen's Univ. (Canada)
Kate Harkness, Queen's Univ. (Canada)

Published in SPIE Proceedings Vol. 8669:
Medical Imaging 2013: Image Processing
Sebastien Ourselin; David R. Haynor, Editor(s)

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