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Proceedings Paper

Multi-system comparison of optical coherence tomography performance with point spread function phantoms
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Paper Abstract

Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have proven effective for evaluating resolution and its spatial variation in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, submicron-diameter iron oxide particles and 1.5-micron-diameter silica particles. The OCT systems included spectral-domain and swept source systems in free-beam geometries as well as a time-domain system in both free-beam and fiberoptic probe geometries. Results indicated that iron oxide particles and gold nanoshells were most effective for measuring spatial variations in the magnitude and shape of PSFs across the image volume. The intensity of individual particles was also used to evaluate spatial variations in signal intensity uniformity. Significant system-to-system differences in resolution and signal intensity and their spatial variation were readily quantified. The phantoms proved useful for identification and characterization of irregularities such as astigmatism. Particle concentrations of 5000 per cubic millimeter or greater provided accurate determination of performance metrics. Our multi-system inter-comparison provides evidence of the effectiveness of PSF-phantom-based test methods for comparison of OCT system resolution and signal uniformity.

Paper Details

Date Published: 13 March 2013
PDF: 10 pages
Proc. SPIE 8573, Design and Quality for Biomedical Technologies VI, 85730C (13 March 2013); doi: 10.1117/12.2007005
Show Author Affiliations
Joshua Pfefer, U.S. Food and Drug Administration (United States)
Anthony Fouad, U.S. Food and Drug Administration (United States)
The Univ. of Maryland (United States)
Chao-Wei Chen, U.S. Food and Drug Administration (United States)
The Univ. of Maryland (United States)
Wei Gong, U.S. Food and Drug Administration (United States)
The Univ. of Maryland (United States)
Fujian Normal Univ. (China)
Peter Tomlins, Queen Mary Univ. of London (United Kingdom)
Peter Woolliams, National Physical Lab. (United Kingdom)
Rebekah Drezek, Rice Univ. (United States)
Anant Agrawal, U.S. Food and Drug Administration (United States)
Yu Chen, The Univ. of Maryland (United States)

Published in SPIE Proceedings Vol. 8573:
Design and Quality for Biomedical Technologies VI
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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