
Proceedings Paper
Dual-wavelength photothermal optical coherence tomography for blood oxygen saturation measurementFormat | Member Price | Non-Member Price |
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Paper Abstract
We report design and demonstration of a dual wavelength photothermal (DWP) optical coherence tomography (OCT)
system for imaging of a phantom microvessel and measurement of hemoglobin oxygen saturation (SO2) level. The
DWP-OCT system contains a swept-source (SS) two-beam phase-sensitive (PhS) OCT system (1060 nm) and two
intensity modulated photothermal excitation lasers (770 nm and 800 nm). The PhS-OCT probe beam (1060 nm) and
photothermal excitation beams are combined into one single-mode optical fiber. A galvanometer based two-dimensional
achromatic scanning system is designed to provide 14 μm lateral resolution for the PhS-OCT probe beam (1060 nm) and
13 μm lateral resolution for photothermal excitation beams. DWP-OCT system’s sensitivity is 102 dB, axial resolution is
13 μm in tissue and uses a real-time digital dispersion compensation algorithm. Noise floor for optical pathlength
measurements is 300 pm in the signal frequency range (380-400 Hz) of photothermal modulation frequencies. Blood
SO2 level is calculated from measured optical pathlength (op) signal in a 300 μm diameter microvessel phantom
introduced by the two photothermal excitation beams. En-face and B-scan images of a phantom microvessel are recorded,
and six blood samples’ SO2 levels are measured using DWP-OCT and compared with values provided by a commercial
blood oximeter. A mathematical model indicates thermal diffusion introduces a systematic artifact that over-estimates
SO2 values and is consistent with measured data.
Paper Details
Date Published: 20 March 2013
PDF: 7 pages
Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 857103 (20 March 2013); doi: 10.1117/12.2006945
Published in SPIE Proceedings Vol. 8571:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)
PDF: 7 pages
Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 857103 (20 March 2013); doi: 10.1117/12.2006945
Show Author Affiliations
Biwei Yin, The Univ. of Texas at Austin (United States)
Roman V. Kuranov, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Roman V. Kuranov, Univ. of Texas Health Science Ctr. at San Antonio (United States)
Austin B. McElroy, The Univ. of Texas at Austin (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)
Thomas E. Milner, The Univ. of Texas at Austin (United States)
Published in SPIE Proceedings Vol. 8571:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)
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