
Proceedings Paper
The effect of cross-scatter correction on the performance of dual energy micro-CTFormat | Member Price | Non-Member Price |
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Paper Abstract
Dual energy (DE) CT imaging is expected to play a major role in the diagnostic arena as it provides a quantitative
decomposition of basis materials, opening the door for new clinical applications without significantly increasing dose to
the patient. DE-CT provides a particularly unique opportunity in preclinical CT where new elemental contrast agents are
providing novel approaches for quantitative tissue characterization. We have implemented DE-CT imaging with a
preclinical dual source micro-CT scanner. With this configuration, both forward and cross-scatter can substantially
degrade image quality. This work investigated the effect of scatter correction on the accuracy of post-reconstruction
iodine and calcium decomposition. Scatter has been estimated using a lead beam stop technique. Our approach involves
noise reduction in the scatter corrected images using bilateral filtering. The scatter correction has been quantitatively
evaluated using phantom experiments and in vivo cancer imaging. As shown by our measurements, the dual source
scanning is affected more by the cross-scatter from the high energy to the low energy imaging chain. The scatter
correction reduced the presence of cupping artifacts and increased both the accuracy and precision of dual energy
decompositions of calcium and iodine. On average, the root mean square errors in retrieving true iodine and calcium
concentrations via dual energy were reduced by 32%. As a result of scatter corrections, we expect more accurate
quantification of important vascular biomarkers such as fractional blood volume and vascular permeability in preclinical
cancer studies.
Paper Details
Date Published: 6 March 2013
PDF: 10 pages
Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86684T (6 March 2013); doi: 10.1117/12.2006904
Published in SPIE Proceedings Vol. 8668:
Medical Imaging 2013: Physics of Medical Imaging
Robert M. Nishikawa; Bruce R. Whiting; Christoph Hoeschen, Editor(s)
PDF: 10 pages
Proc. SPIE 8668, Medical Imaging 2013: Physics of Medical Imaging, 86684T (6 March 2013); doi: 10.1117/12.2006904
Show Author Affiliations
D. Clark, Ctr. for In Vivo Microscopy, Duke Univ. Medical Ctr. (United States)
S. M. Johnston, Ctr. for In Vivo Microscopy, Duke Univ. Medical Ctr. (United States)
S. M. Johnston, Ctr. for In Vivo Microscopy, Duke Univ. Medical Ctr. (United States)
G. A. Johnson, Ctr. for In Vivo Microscopy, Duke Univ. Medical Ctr. (United States)
C. T. Badea, Ctr. for In Vivo Microscopy, Duke Univ. Medical Ctr. (United States)
C. T. Badea, Ctr. for In Vivo Microscopy, Duke Univ. Medical Ctr. (United States)
Published in SPIE Proceedings Vol. 8668:
Medical Imaging 2013: Physics of Medical Imaging
Robert M. Nishikawa; Bruce R. Whiting; Christoph Hoeschen, Editor(s)
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