
Proceedings Paper
Mouse lung volume reconstruction from efficient groupwise registration of individual histological slices with natural gradientFormat | Member Price | Non-Member Price |
---|---|---|
$17.00 | $21.00 |
Paper Abstract
Mouse lung models facilitate the study of the pathogenesis of various pulmonary diseases such as infections and inflammatory
diseases. The co-registration of ex vivo histological data and pre-excised magnetic resonance imaging (MRI) in
preclinical mouse models would allow for determination and validation of imaging signatures for different pathobiologies
within the lung. While slice-based co-registration could be used, this approach assumes that (a) slice correspondences between
the two different modalities exist, and (b) finding slice correspondences often requires the intervention of an expert
and is time consuming. A more practical approach is to first reconstruct the 3D histological volume from individual slices,
then perform 3D registration with the MR volume. Before the histological reconstruction, image registration is required to
compensate for geometric differences between slices. Pairwise algorithms work by registering pairs of successive slices.
However, even if successive slices are registered reasonably well, the propagation of registration errors over slices can
yield a distorted volumetric reconstruction significantly different in shape from the shape of the true specimen. Groupwise
registration can reduce the error propagation by considering more than two successive images during the registration, but
existing algorithms are computationally expensive. In this paper, we present an efficient groupwise registration approach,
which yields consistent volumetric reconstruction and yet runs equally fast as pairwise registration. The improvements are
based on 1) natural gradient which speeds up the transform warping procedure and 2) efficient optimization of the cost
function of our groupwise registration. The strength of the natural gradient technique is that it could help mitigate the impact
of the uncertainties of the gradient direction across multiple template slices. Experiments on two mouse lung datasets
show that compared to pairwise registration, our groupwise approach runs faster in terms of registration convergence, and
yields globally more consistent reconstruction.
Paper Details
Date Published: 13 March 2013
PDF: 11 pages
Proc. SPIE 8669, Medical Imaging 2013: Image Processing, 866914 (13 March 2013); doi: 10.1117/12.2006860
Published in SPIE Proceedings Vol. 8669:
Medical Imaging 2013: Image Processing
Sebastien Ourselin; David R. Haynor, Editor(s)
PDF: 11 pages
Proc. SPIE 8669, Medical Imaging 2013: Image Processing, 866914 (13 March 2013); doi: 10.1117/12.2006860
Show Author Affiliations
Haibo Wang, Case Western Reserve Univ. (United States)
Mirabela Rusu, Case Western Reserve Univ. (United States)
Thea Golden, Rutgers, The State Univ. of New Jersey (United States)
Mirabela Rusu, Case Western Reserve Univ. (United States)
Thea Golden, Rutgers, The State Univ. of New Jersey (United States)
Andrew Gow, Rutgers, The State Univ. of New Jersey (United States)
Anant Madabhushi, Case Western Reserve Univ. (United States)
Anant Madabhushi, Case Western Reserve Univ. (United States)
Published in SPIE Proceedings Vol. 8669:
Medical Imaging 2013: Image Processing
Sebastien Ourselin; David R. Haynor, Editor(s)
© SPIE. Terms of Use
