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Proceedings Paper

Measurement of angle-resolved scattering property of ovarian tissue by use of OCT
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Paper Abstract

Angle-resolved optical scattering properties of ovarian tissue on different optical coherence tomography (OCT) imaging planes were quantitatively measured by fitting the compounded OCT A-lines into a single scattering model. Higher cross correlation value of angle-resolved scattering coefficients between different OCT imaging planes was found in normal ovaries than was present in malignant ovaries. The mean cross correlation coefficient (MCC) was introduced in this pilot study to characterize and differentiate normal and malignant ovaries. A specificity of 100% and a sensitivity of 100% were achieved by setting MCC threshold at 0.6 in the limited sample population. The collagen properties such as content, structure and directivity were found to be different within OCT imaging penetration depth between normal and malignant ovarian tissue. The homogeneous three-dimensional collagen fiber network observed in the normal ovary effectively explains the stronger cross correlation of angle-resolved scattering properties on different imaging planes while the heterogeneity observed in the malignant ovary suggests a weaker correlation.

Paper Details

Date Published: 20 March 2013
PDF: 6 pages
Proc. SPIE 8571, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, 85711Q (20 March 2013); doi: 10.1117/12.2006848
Show Author Affiliations
Yi Yang, Univ. of Connecticut (United States)
Tianheng Wang, Univ. of Connecticut (United States)
Molly Brewer, Univ. of Connecticut (United States)
Univ. of Connecticut Health Ctr. (United States)
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 8571:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
James G. Fujimoto; Joseph A. Izatt; Valery V. Tuchin, Editor(s)

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