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Proceedings Paper

Comparison of the effects of millimeter wave irradiation, general bath heating, and localized heating on neuronal activity in the leech ganglion
Author(s): Sergii Romanenko; Peter H. Siegel; Daniel A. Wagenaar; Victor Pikov
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Paper Abstract

The use of electrically-induced neuromodulation has grown in importance in the treatment of multiple neurological disorders such as Parkinson’s disease, dystonia, epilepsy, chronic pain, cluster headaches and others. While electrical current can be applied locally, it requires placing stimulation electrodes in direct contact with the neural tissue. Our goal is to develop a method for localized application of electromagnetic energy to the brain without direct tissue contact. Toward this goal, we are experimenting with the wireless transmission of millimeter wave (MMW) energy in the 10-100 GHz frequency range, where penetration and focusing can be traded off to provide non-contact irradiation of the cerebral cortex. Initial experiments have been conducted on freshly-isolated leech ganglia to evaluate the real-time changes in the activity of individual neurons upon exposure to the MMW radiation. The initial results indicate that low-intensity MMWs can partially suppress the neuronal activity. This is in contrast to general bath heating, which had an excitatory effect on the neuronal activity. Further studies are underway to determine the changes in the state of the membrane channels that might be responsible for the observed neuromodulatory effects.

Paper Details

Date Published: 23 February 2013
PDF: 10 pages
Proc. SPIE 8585, Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications, 85850N (23 February 2013); doi: 10.1117/12.2006504
Show Author Affiliations
Sergii Romanenko, California Institute of Technology (United States)
Peter H. Siegel, California Institute of Technology (United States)
Daniel A. Wagenaar, California Institute of Technology (United States)
Victor Pikov, Huntington Medical Research Institutes (United States)

Published in SPIE Proceedings Vol. 8585:
Terahertz and Ultrashort Electromagnetic Pulses for Biomedical Applications
Gerald J. Wilmink; Bennett L. Ibey, Editor(s)

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