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Proceedings Paper

Monitoring of the degradation in the rat's articular cartilage inducing osteoarthritis using common-path Fourier-domain optical coherence tomography
Author(s): D. H. Shin; S. H. Park; B. Y. Kim; M. Y. Lee; H. K. Baik; J. H. Seo; J. U. Kang; C. G. Song
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Paper Abstract

The objective of this experiment is to evaluate the utility and limitations of optical coherence tomography (OCT) for real-time, high-resolution structural analysis. We monitored the degradation of the rat’s articular cartilage inducing osteoarthritis (OA) and the change of the rat’s articular cartilage recovery by treatment medication, using our developed common-path Fourier-domain (CP-FD) OCT. Also, we have done a comparative analysis the rat’s articular cartilage and OA grade. To observe the progression of OA, we induced OA by injecting the monosodium iodoacetate (MIA) into the right knee joint. After the injection of MIA, we sacrificed the rats at intervals of 3 days and obtained OCT and histological images. OCT and histological images showed the OA progress of similar pattern. These results illustrated the potential for non-invasive diagnosis about the grade of OA using CP-FD OCT.

Paper Details

Date Published: 20 March 2013
PDF: 6 pages
Proc. SPIE 8576, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII, 85760Z (20 March 2013); doi: 10.1117/12.2006463
Show Author Affiliations
D. H. Shin, Chonbuk National Univ. (Korea, Republic of)
S. H. Park, Chonbuk National Univ. (Korea, Republic of)
B. Y. Kim, Chonbuk National Univ. (Korea, Republic of)
M. Y. Lee, Chonbuk National Univ. (Korea, Republic of)
H. K. Baik, Chonbuk National Univ. (Korea, Republic of)
J. H. Seo, Chonbuk National Univ. (Korea, Republic of)
J. U. Kang, Johns Hopkins Univ. (United States)
C. G. Song, Chonbuk National Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 8576:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIII
Israel Gannot, Editor(s)

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