
Proceedings Paper
Bias correction of maximum likelihood estimation in quantitative MRIFormat | Member Price | Non-Member Price |
---|---|---|
$17.00 | $21.00 |
Paper Abstract
For quantitative MRI techniques, such as T1, T2 mapping and Diffusion Tensor Imaging (DTI), a model has to be
fit to several MR images that are acquired with suitably chosen different acquisition settings. The most efficient
estimator to retrieve the parameters is the Maximum Likelihood (ML) estimator. However, the standard ML
estimator is biased for finite sample sizes. In this paper we derive a bias correction formula for magnitude MR
images. This correction is applied in two different simulation experiments, a T2 mapping experiment and a DTI
experiment. We show that the correction formula successfully removes the bias. As the correction is performed
as post-processing, it is possible to retrospectively correct the results of previous quantitative experiments. With
this procedure more accurate quantitative values can be obtained from quantitative MR acquisitions.
Paper Details
Date Published: 13 March 2013
PDF: 6 pages
Proc. SPIE 8669, Medical Imaging 2013: Image Processing, 86691F (13 March 2013); doi: 10.1117/12.2006407
Published in SPIE Proceedings Vol. 8669:
Medical Imaging 2013: Image Processing
Sebastien Ourselin; David R. Haynor, Editor(s)
PDF: 6 pages
Proc. SPIE 8669, Medical Imaging 2013: Image Processing, 86691F (13 March 2013); doi: 10.1117/12.2006407
Show Author Affiliations
W. J. Niessen, Erasmus MC (Netherlands)
Delft Univ. of Technology (Netherlands)
S. Klein, Erasmus MC (Netherlands)
Delft Univ. of Technology (Netherlands)
S. Klein, Erasmus MC (Netherlands)
Published in SPIE Proceedings Vol. 8669:
Medical Imaging 2013: Image Processing
Sebastien Ourselin; David R. Haynor, Editor(s)
© SPIE. Terms of Use
