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Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative
Author(s): Zenghai Lu; Joseph Boadi; Simon Danby; Michael Cork; Stephen J. Matcher
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Paper Abstract

The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In one of 4 subjects we found evidence that the epidermis was actually thickened following treatment using Tacrolimus.

Paper Details

Date Published: 8 March 2013
PDF: 7 pages
Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85650C (8 March 2013); doi: 10.1117/12.2006104
Show Author Affiliations
Zenghai Lu, Univ. of Sheffield (United Kingdom)
Joseph Boadi, Univ. of Sheffield (United Kingdom)
Simon Danby, Univ. of Sheffield (United Kingdom)
Michael Cork, Univ. of Sheffield (United Kingdom)
Stephen J. Matcher, Univ. of Sheffield (United Kingdom)

Published in SPIE Proceedings Vol. 8565:
Photonic Therapeutics and Diagnostics IX
Andreas Mandelis; Brian Jet-Fei Wong; Anita Mahadevan-Jansen; Henry Hirschberg M.D.; Hyun Wook Kang; Nikiforos Kollias; Melissa J. Suter; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Stephen Lam; Bernard Choi; Steen J. Madsen; Bodo E. Knudsen M.D.; E. Duco Jansen; Justus F. Ilgner M.D.; Haishan Zeng; Matthew Brenner; Laura Marcu, Editor(s)

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