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Proceedings Paper

Dynamic SERS imaging with gold nanoparticles transported in a living cell
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Paper Abstract

Surface enhanced Raman scattering (SERS) has been used to detect biological molecules at a low concentration. We developed a rapid Raman imaging system, which can image dynamic activity of SERS agents, such as gold nanoparticles, in a living cell and the temporal behaviors of SERS spectra. Combination of slit scanning and an EM-CCD camera for measuring SERS spectra enables us to obtain a SERS image in a few seconds. The system can also be used to track a single particle moving in a cell with a laser focus and measure SERS spectra with a temporal resolution of 50 msec. By using the developed microscope systems, we monitored the change of SERS spectra associated cell transportation functions.

Paper Details

Date Published: 21 February 2013
PDF: 6 pages
Proc. SPIE 8597, Plasmonics in Biology and Medicine X, 859707 (21 February 2013); doi: 10.1117/12.2005820
Show Author Affiliations
Katsumasa Fujita, Osaka Univ. (Japan)
Jun Ando, Osaka Univ. (Japan)
Nicholas I. Smith, Osaka Univ. (Japan)
Satoshi Kawata, Osaka Univ. (Japan)
RIKEN (Japan)

Published in SPIE Proceedings Vol. 8597:
Plasmonics in Biology and Medicine X
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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