
Proceedings Paper
Disassembly of myofibrils in adult cardiomyocytes during dedifferentiationFormat | Member Price | Non-Member Price |
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Paper Abstract
Using hybrid TPEF-SHG imaging and immunocytological techniques, we studied dedifferentiation of adult
cardiomyocytes. First, the myofibrils shrank to shorten the sarcomere length. At the cell ends, the striated pattern of
myosin filaments began to dissociate; at the center of the cell, the striated pattern of alpha-actinin first faded away and
reappeared near the cell membrane during dedifferentiation. The results suggest that when freshly isolated adult
cardiomyocytes are used to model cardiac muscle, the end-to-end connection may be important to maintain their striated
myofibrillar structure and rod-shape morphology.
Paper Details
Date Published: 26 February 2013
PDF: 7 pages
Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 85871W (26 February 2013); doi: 10.1117/12.2005156
Published in SPIE Proceedings Vol. 8587:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)
PDF: 7 pages
Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 85871W (26 February 2013); doi: 10.1117/12.2005156
Show Author Affiliations
Honghai Liu, Clemson Univ. (United States)
Wan Qin, Clemson Univ. (United States)
Yonghong Shao, Shenzhen Univ. (China)
Zhonghai Wang, Clemson Univ. (United States)
Wan Qin, Clemson Univ. (United States)
Yonghong Shao, Shenzhen Univ. (China)
Zhonghai Wang, Clemson Univ. (United States)
Huaxiao Yang, Clemson Univ. (United States)
Raymond B. Runyan, The Univ. of Arizona (United States)
Thomas K. Borg, Medical Univ. of South Carolina (United States)
Bruce Gao, Clemson Univ. (United States)
Raymond B. Runyan, The Univ. of Arizona (United States)
Thomas K. Borg, Medical Univ. of South Carolina (United States)
Bruce Gao, Clemson Univ. (United States)
Published in SPIE Proceedings Vol. 8587:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)
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