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Proceedings Paper

Biomimetic polydopamine coating on gold nanorods for biofunctionalization, imaging, and photothermal therapy
Author(s): Kvar C. L. Black; Ji Yi; José G. Rivera; Daria C. Zelasko-Leon; Phillip B. Messersmith
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Paper Abstract

A biomimetic polydopamine (PD)-based strategy was employed for presenting antibodies on gold nanorods (NRs) to target cancer cells for photothermal therapy. PD was polymerized onto NRs, and epidermal growth factor receptor antibodies (anti-EGFR) were immobilized onto the layer. Anti-EGFR-PD-NRs specifically bound to EGFRoverexpressing cells as quantified by optical coherence tomography, and illumination enhanced cell death compared to non-irradiated or antibody-free controls.

Paper Details

Date Published: 12 April 2013
PDF: 5 pages
Proc. SPIE 8598, Bioinspired, Biointegrated, Bioengineered Photonic Devices, 85980D (12 April 2013); doi: 10.1117/12.2005041
Show Author Affiliations
Kvar C. L. Black, Northwestern Univ. (United States)
Washington Univ. School of Medicine in St. Louis (United States)
Ji Yi, Northwestern Univ. (United States)
José G. Rivera, Northwestern Univ. (United States)
Daria C. Zelasko-Leon, Northwestern Univ. (United States)
Phillip B. Messersmith, Northwestern Univ. (United States)

Published in SPIE Proceedings Vol. 8598:
Bioinspired, Biointegrated, Bioengineered Photonic Devices
Luke P. Lee; John A. Rogers; Seok-Hyun Yun, Editor(s)

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