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Proceedings Paper

A novel fiber laser development for photoacoustic microscopy
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Paper Abstract

Photoacoustic microscopy, as an imaging modality, has shown promising results in imaging angiogenesis and cutaneous malignancies like melanoma, revealing systemic diseases including diabetes, hypertension, tracing drug efficiency and assessment of therapy, monitoring healing processes such as wound cicatrization, brain imaging and mapping. Clinically, photoacoustic microscopy is emerging as a capable diagnostic tool. Parameters of lasers used in photoacoustic microscopy, particularly, pulse duration, energy, pulse repetition frequency, and pulse-to-pulse stability affect signal amplitude and quality, data acquisition speed and indirectly, spatial resolution. Lasers used in photoacoustic microscopy are typically Q-switched lasers, low-power laser diodes, and recently, fiber lasers. Significantly, the key parameters cannot be adjusted independently of each other, whereas microvasculature and cellular imaging, e.g., have different requirements. Here, we report an integrated fiber laser system producing nanosecond pulses, covering the spectrum from 600 nm to 1100 nm, developed specifically for photoacoustic excitation. The system comprises of Yb-doped fiber oscillator and amplifier, an acousto-optic modulator and a photonic-crystal fiber to generate supercontinuum. Complete control over the pulse train, including generation of non-uniform pulse trains, is achieved via the AOM through custom-developed field-programmable gate-array electronics. The system is unique in that all the important parameters are adjustable: pulse duration in the range of 1-3 ns, pulse energy up to 10 μJ, repetition rate from 50 kHz to 3 MHz. Different photocoustic imaging probes can be excited with the ultrabroad spectrum. The entire system is fiber-integrated; guided-beam-propagation rendersit misalignment free and largely immune to mechanical perturbations. The laser is robust, low-cost and built using readily available components.

Paper Details

Date Published: 4 March 2013
PDF: 5 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85813S (4 March 2013); doi: 10.1117/12.2004910
Show Author Affiliations
Seydi Yavas, Bilkent Univ. (Turkey)
Esra Aytac-Kipergil, Bogazici Univ. (Turkey)
Mustafa U. Arabul, Bogazici Univ. (Turkey)
Hakan Erkol, Bogazici Univ. (Turkey)
Onder Akcaalan, Bilkent Univ. (Turkey)
Y. Burak Eldeniz, Ankara Univ. (Turkey)
F. Omer Ilday, Bilkent Univ. (Turkey)
Mehmet B. Unlu, Bogazici Univ. (Turkey)

Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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