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Proceedings Paper

Oblique polarized reflectance spectroscopy for depth sensitive measurements in the epithelial tissue
Author(s): Maria K. Jimenez; Leonid Fradkin; Linda T. Nieman; Sylvia Lam; Catherine Poh; Konstantin Sokolov
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Paper Abstract

Optical spectroscopy has shown potential as a tool for precancer detection by discriminating alterations in the optical properties within epithelial tissues. Identifying depth-dependent alterations associated with the progression of epithelial cancerous lesions can be especially challenging in the oral cavity due to the variable thickness of the epithelium and the presence of keratinization. Optical spectroscopy of epithelial tissue with improved depth resolution would greatly assist in the isolation of optical properties associated with cancer progression. Here, we report a fiber optic probe for oblique polarized reflectance spectroscopy (OPRS) that is capable of depth sensitive detection by combining the following three approaches: multiple beveled fibers, oblique collection geometry, and polarization gating. We analyze how probe design parameters are related to improvements in collection efficiency of scattered photons from superficial tissue layers and to increased depth discrimination within epithelium. We have demonstrated that obliquely-oriented collection fibers increase both depth selectivity and collection efficiency of scattering signal. Currently, we evaluate this technology in a clinical trial of patients presenting lesions suspicious for dysplasia or carcinoma in the oral cavity. We use depth sensitive spectroscopic data to develop automated algorithms for analysis of morphological and architectural changes in the context of the multilayer oral epithelial tissue. Our initial results show that OPRS has the potential to improve the detection and monitoring of epithelial precancers in the oral cavity.

Paper Details

Date Published: 21 February 2013
PDF: 8 pages
Proc. SPIE 8592, Biomedical Applications of Light Scattering VII, 859203 (21 February 2013); doi: 10.1117/12.2004875
Show Author Affiliations
Maria K. Jimenez, The Univ. of Texas at Austin (United States)
Leonid Fradkin, The Univ. of Texas at Austin (United States)
Linda T. Nieman, The Univ. of Texas MD Anderson Cancer Ctr. (United States)
Sylvia Lam, BC Cancer Agency (Canada)
Catherine Poh, BC Cancer Agency (Canada)
Konstantin Sokolov, The Univ. of Texas at Austin (United States)
The Univ. of Texas MD Anderson Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 8592:
Biomedical Applications of Light Scattering VII
Adam P. Wax; Vadim Backman, Editor(s)

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