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Proceedings Paper

Toward ideal imaging geometry for recovery independence in fluorescence molecular tomography
Author(s): Robert W. Holt; Frederic Leblond; Brian W. Pogue
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Paper Abstract

An established challenge with fluorescence molecular tomography is inconsistent accuracy in quantifying recovered fluorescent contrast with changes in target depth. This work examines the idea that through optimization of the source and detector placement more consistent contrast could be recovered regardless of imaging depth. A simulation study was performed to examine distributions of optical projection measurements result in a uniform summed sensitivity function, showing that half-reflectance and transmission measurements are the most important for accurate and consistent target recovery as a function of depth. As a corollary to the importance of uniform summed sensitivity, translation modulated reconstructions are shown to provide improvements in fluorescence tomography.

Paper Details

Date Published: 13 March 2013
PDF: 10 pages
Proc. SPIE 8574, Multimodal Biomedical Imaging VIII, 857403 (13 March 2013); doi: 10.1117/12.2004870
Show Author Affiliations
Robert W. Holt, Dartmouth College (United States)
Frederic Leblond, Ecole Polytechnique de Montréal (Canada)
Brian W. Pogue, Dartmouth College (United States)
Thayer School of Engineering at Dartmouth (United States)

Published in SPIE Proceedings Vol. 8574:
Multimodal Biomedical Imaging VIII
Fred S. Azar; Xavier Intes, Editor(s)

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