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Proceedings Paper

Hyperspectral angular domain imaging for ex-vivo breast tumor detection
Author(s): Fartash Vasefi; Bozena Kaminska; Muriel Brackstone; Jeffrey J. L. Carson
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Paper Abstract

An angular domain spectroscopic imaging system was built and validated using fresh ex vivo breast tissue samples (~ 2 mm thick). The hyperspectral system consisted of a halogen lamp, collimation optics, scanning stage with controller, a silicon micro-machined micro-channel array, and a pushbroom spectral imager. As a proof of concept, spectral data cubes acquired from tissue samples were input into principal component analysis and Mahalanobis discriminant analysis to differentiate between spectral signatures of breast tumor and normal tissue. It is proposed that the results from training sets can be used to construct a set of classifiers to enable tumor detection in samples representative of the surgical margins.

Paper Details

Date Published: 20 June 2013
PDF: 8 pages
Proc. SPIE 8587, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI, 85870S (20 June 2013); doi: 10.1117/12.2004663
Show Author Affiliations
Fartash Vasefi, Univ. of Western Ontario (United States)
Lawson Health Research Institute (Canada)
Simon Fraser Univ. (Canada)
Bozena Kaminska, Simon Fraser Univ. (Canada)
Muriel Brackstone, London Regional Cancer Program (Canada)
Univ. of Western Ontario (Canada)
Jeffrey J. L. Carson, Univ. of Western Ontario (Canada)
Lawson Health Research Institute (Canada)

Published in SPIE Proceedings Vol. 8587:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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