
Proceedings Paper
Dynamic contrast-enhanced 3D photoacoustic imagingFormat | Member Price | Non-Member Price |
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Paper Abstract
Photoacoustic imaging (PAI) is a hybrid imaging modality that integrates the strengths from both optical imaging and
acoustic imaging while simultaneously overcoming many of their respective weaknesses. In previous work, we reported
on a real-time 3D PAI system comprised of a 32-element hemispherical array of transducers. Using the system, we
demonstrated the ability to capture photoacoustic data, reconstruct a 3D photoacoustic image, and display select slices of
the 3D image every 1.4 s, where each 3D image resulted from a single laser pulse. The present study aimed to exploit the
rapid imaging speed of an upgraded 3D PAI system by evaluating its ability to perform dynamic contrast-enhanced
imaging. The contrast dynamics can provide rich datasets that contain insight into perfusion, pharmacokinetics and
physiology. We captured a series of 3D PA images of a flow phantom before and during injection of piglet and rabbit
blood. Principal component analysis was utilized to classify the data according to its spatiotemporal information. The
results suggested that this technique can be used to separate a sequence of 3D PA images into a series of images
representative of main features according to spatiotemporal flow dynamics.
Paper Details
Date Published: 4 March 2013
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858152 (4 March 2013); doi: 10.1117/12.2004647
Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)
PDF: 6 pages
Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858152 (4 March 2013); doi: 10.1117/12.2004647
Show Author Affiliations
Philip Wong, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Ivan Kosik, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Univ. of Western Ontario (Canada)
Ivan Kosik, Lawson Health Research Institute (Canada)
Univ. of Western Ontario (Canada)
Published in SPIE Proceedings Vol. 8581:
Photons Plus Ultrasound: Imaging and Sensing 2013
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)
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